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PubMed · 15192281

A new method for computing the multipoint posterior probability of linkage.

Mark W Logue·Veronica J Vieland
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Abstract

The posterior probability of linkage (PPL) is a Bayesian statistic which directly measures the probability of linkage between a trait locus and a marker (in the 2-point case) or a genomic region (in the multipoint case). It has several benefits, including ease of interpretation, the ability to incorporate prior genomic information, and a mathematically rigorous and robust procedure for accumulating linkage information across multiple heterogeneous datasets. To date, the majority of work on the PPL has focused on the development of the 2-point statistic, with only preliminary attempts at the development of an equivalent multipoint version. In this paper we present a new way of computing of the multipoint PPL. This new version imputes to each genomic point an estimate of the 2-point PPL we would have obtained from a fully informative marker giving similar evidence for linkage. This version, which we call the imputed PPL, is shown to be superior to previously developed versions.

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Bayes TheoremComputational BiologyGenetic LinkageGenetic MarkersHumansModels, GeneticMultifactorial InheritanceProbabilityStatistics as TopicJournal Article

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Mark W Logue, Veronica J Vieland. 2004. A new method for computing the multipoint posterior probability of linkage.. https://doi.org/10.1159/000077546

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