Setting up a selective barrier at the apical junction complex.

James Melvin Anderson; Christina M Van Itallie; Alan S Fanning

doi:10.1016/j.ceb.2004.01.005

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Setting up a selective barrier at the apical junction complex.

James Melvin Anderson·Christina M Van Itallie·Alan S Fanning

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Abstract

Across the animal kingdom the apical junction complex of epithelial cells creates both a permeability barrier and cell polarity. Although based on overlapping and evolutionarily conserved proteins, the cell-cell contacts of nematodes, flies and mammals appear to differ in morphology and functional organization. Emerging evidence shows that the selective pore-like properties of vertebrate and invertebrate barriers are created by the claudin family. Similarly, assembly of the barriers requires a conserved set of polarity-generating protein complexes, particularly the PAR protein complexes.

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Adherens Junctions Animals Cell Membrane Permeability Cell Polarity Claudin-1 Epithelial Cells Evolution, Molecular Humans Membrane Proteins Species Specificity Tight Junctions Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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James Melvin Anderson, Christina M Van Itallie, Alan S Fanning. 2004. Setting up a selective barrier at the apical junction complex.. https://doi.org/10.1016/j.ceb.2004.01.005

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