[Cell protection through PPAR nuclear receptor activation].

Dominique Deplanque

doi:10.2515/therapie:2004006

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PubMed · 15199664

[Cell protection through PPAR nuclear receptor activation].

Dominique Deplanque

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Abstract

Apart from their effects on lipid and glucose metabolism, the nuclear receptors PPARs (peroxysome proliferator-activated receptors) could also be involved in cellular protection. Indeed, an increasing body of literature provides arguments in favour of a protective role of PPAR alpha (fenofibrate, gemfibrozil) and PPAR gamma (ciglitazone, pioglitazone, rosiglitazone, troglitazone) agonists, particularly in myocardial or cerebral ischaemia as well as in neurodegenerative diseases. Such cellular protection could be the result of the modulation, at a molecular level, of inflammation pathways, oxidative stress and apoptosis. If these experimental results are confirmed by appropriate clinical trials, pharmacological modulation of the nuclear receptor PPARs, as well as the development of highly selective and more effective PPAR agonists, could become an important challenge in the field of cellular protection.

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Animals Apoptosis Brain Ischemia Cell Survival Humans Inflammation Neurons Oxidative Stress Receptors, Cytoplasmic and Nuclear Transcription Factors English Abstract Journal Article Review

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Dominique Deplanque. [Cell protection through PPAR nuclear receptor activation].. https://doi.org/10.2515/therapie%3A2004006

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