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PubMed · 1520828

Controlled cisplatin delivery system using poly(D,L-lactic acid).

O Ike·Y Shimizu·R Wada·S H Hyon·Y Ikada
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Abstract

Cisplatin (CDDP)-containing poly(D,L-lactic acid) microspheres (CDDP-MS) and beads (CDDP-B) with an average molecular weight of the oligomer of 1.2 x 10(4) and 4% CDDP loading were prepared. In Tris buffer, 95% of CDDP disappeared from CDDP-MS within 3 d. In vitro and in vivo, CDDP-B released CDDP for 30-57 d, and for 21-42 d, respectively. The other CDDP-B with an average oligomer molecular weight of 9.6 x 10(3) with 5% lactic acid monomers, that contained 4% CDDP, showed a two-phase CDDP release pattern and CDDP disappeared within 41 d in vitro, and within 21 d in vivo. Histologically, tissue necrosis surrounding the CDDP-B was not severe.

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AnimalsChemistry, PharmaceuticalCisplatinDelayed-Action PreparationsLactatesLactic AcidMaleMicrospheresMusclesPolyestersPolymersRabbitsTromethamineJournal Article

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O Ike, Y Shimizu, R Wada, S H Hyon, Y Ikada. 1992. Controlled cisplatin delivery system using poly(D,L-lactic acid).. https://doi.org/10.1016/0142-9612(92)90189-u

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