PubMed · 15208721
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
Jun Qin, Olga Vinogradova, Edward F Plow. 2004-06-15. Integrin bidirectional signaling: a molecular view.. https://doi.org/10.1371/journal.pbio.0020169
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
Such diverse biological processes as the maintenance of tissue architecture and the regulation of cell migration are controlled through dynamic changes in integrin receptor conformation. Early analyses of the mechanisms of shape change by integrins led to the definition of three inter-convertible conformational states: inactive, primed and ligand-occupied. Recent advances reviewed in this article have now shown that the integrin molecule contains a number of flexible joints and connections, leading to a broad spectrum of possible conformational states. This conformational complexity is likely to permit fine-tuning of integrin function through regulation of ligand-binding affinity and intracellular signalling.
Recent structure-function studies of integrins are beginning to unravel the mechanism of signal transduction across the plasma membrane, but controversy exists over the nature of the conformational changes underlying this process.
Explore the source record for details and available documents.