Protein recognition using synthetic surface-targeted agents.

Rishi Jain; Justin T Ernst; Olaf Kutzki; Hyung Soon Park; Andrew D Hamilton

doi:10.1023/b:modi.0000025652.55320.16

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PubMed · 15209160

Protein recognition using synthetic surface-targeted agents.

Rishi Jain·Justin T Ernst·Olaf Kutzki·Hyung Soon Park·Andrew D Hamilton

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Abstract

The design of synthetic agents to disrupt protein-protein interactions has received relatively little attention in recent years. In this review we describe strategies for targeting different types of protein surfaces using mimetics of protein secondary or tertiary structure. In this way strong and selective binding to a protein surface has be achieved and disruption of clinically important protein-protein interactions has been demonstrated in models of human disease.

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Amino Acid Sequence Biochemistry Chymotrypsin Cytochrome-c Peroxidase Cytochromes c Molecular Mimicry Molecular Sequence Data Organic Chemicals Platelet-Derived Growth Factor Protein Conformation Proteins Receptors, Platelet-Derived Growth Factor Journal Article Research Support, U.S. Gov't, P.H.S.Review

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Rishi Jain, Justin T Ernst, Olaf Kutzki, Hyung Soon Park, Andrew D Hamilton. 2004. Protein recognition using synthetic surface-targeted agents.. https://doi.org/10.1023/b%3Amodi.0000025652.55320.16

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