Galectin-3 as a multifunctional protein.

Anna Krześlak; Anna Lipińska

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PubMed · 15213811

Galectin-3 as a multifunctional protein.

Anna Krześlak·Anna Lipińska

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Abstract

Galectin-3 is a 31 kDa member of a growing family of beta-galactoside-binding animal lectins. This protein is expressed in a variety of tissues and cell types and is mainly found in the cytoplasm, although, depending on cell type and proliferative state, a significant amount of this lectin can also be detected in the nucleus, on the cell surface or in the extracellular environment. Galectin-3 is secreted from cells by a novel and incompletely understood mechanism that is independent of the classical secretory pathway through the endoplasmic reticulum/Golgi network. Galectin-3 exhibits pleiotropic biological function, playing a key role in many physiological and pathological processes.

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Animals Apoptosis Carbohydrate Metabolism Carbohydrates Disease Progression Galectin 3 Humans Ligands Molecular Structure Neoplasms Protein Binding Tissue Distribution Journal Article Research Support, Non-U.S. Gov't Review

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Anna Krześlak, Anna Lipińska. 2004. Galectin-3 as a multifunctional protein.. https://pubmed.ncbi.nlm.nih.gov/15213811/

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