Generating new pancreas from old.

Anandwardhan A Hardikar

doi:10.1016/j.tem.2004.05.001

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PubMed · 15223048

Generating new pancreas from old.

Anandwardhan A Hardikar

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Abstract

Pancreas regeneration after tissue damage is a key response to pancreatic injury, involving pancreatic duct progenitor cells and intra-islet precursor cells. Surgical removal of the pancreas, duct obstruction by cellophane wrapping and bone marrow-derived stem cell transplantation act as inductive stimuli, leading to pancreas regeneration. The exact role of growth and differentiation factors regulating pancreatic beta-cell mass remains unknown. Here, I will attempt to integrate recent findings and speculate on the factors that trigger this fascinating response, wherein the pancreas responds to a deficit in cell mass and undergoes new islet formation, leading to restoration of normal beta-cell mass. I will also discuss recent advances in regenerating endocrine pancreatic cells, which could affect stem cell-based approaches to treating diabetes mellitus.

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Animals Diabetes Mellitus, Type 1 Humans Islets of Langerhans Regeneration Journal Article Research Support, U.S. Gov't, P.H.S.Review

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Anandwardhan A Hardikar. 2004. Generating new pancreas from old.. https://doi.org/10.1016/j.tem.2004.05.001

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