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PubMed · 15228102

Sequential genotyping within TDT families.

Mark M Iles·Chris Cannings
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Abstract

We demonstrate that, given a limited amount of genotyping resources, the power of a TDT study can be increased substantially by genotyping within families sequentially. By sequential genotyping we mean that one parent in a family should be typed and then the decision on whether to continue genotyping the family is based on this parent's genotype. If it is decided to continue genotyping then a further decision is made about whether to genotype the offspring once the second parent has been genotyped. We show that, for a given power, reductions in sample size of over 80% are possible, even for the most robust selection strategies. We discuss the practical application of such sequential genotyping and illustrate its potential using a real data set.

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ChildDiabetes Mellitus, Type 1FemaleGenetic Diseases, InbornGenotypeHumansLinkage DisequilibriumMaleModels, GeneticParentsComparative StudyJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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Mark M Iles, Chris Cannings. 2004. Sequential genotyping within TDT families.. https://doi.org/10.1093/imammb%2F21.2.115

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