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PubMed · 15230348

2'-Functionalized nucleic acids as structural tools in molecular biology.

Timofei S Zatsepin·Michael J Gait·Tatiana S Oretskaya
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Abstract

Modified oligonucleotides bearing 2'-reactive groups or 2'-conjugated molecules have found wide application as structural tools in molecular biology. Of principal interest has been the use of 2'-reactive oligonucleotides for cross-linking with biomolecules and of 2'-conjugated oligonucleotides in hybridization assays. In this review we compare a range of electrophilic, nucleophilic and photoreactive groups for cross-linking and conjugation studies.

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Cross-Linking ReagentsDNA ProbesMolecular BiologyOligonucleotidesRNAJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Timofei S Zatsepin, Michael J Gait, Tatiana S Oretskaya. 2004. 2'-Functionalized nucleic acids as structural tools in molecular biology.. https://doi.org/10.1080/15216540410001710570

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