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PubMed · 15231033

Carbohydrate-based therapeutics.

Helen M I Osborn·Philip G Evans·Natasha Gemmell·Sadie D Osborne
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Abstract

In recent years there has been a resurgence of interest in the biological roles of carbohydrates and as a result it is now known that carbohydrates are involved in a vast array of disease processes. This review summarises progress in the development of carbohydrate-based therapeutics that involve: inhibition of carbohydrate-lectin interactions; immunisation, using monoclonal antibodies for carbohydrate antigens; inhibition of enzymes that synthesise disease-associated carbohydrates; replacement of carbohydrate-processing enzymes; targeting of drugs to specific disease cells via carbohydrate-lectin interactions; carbohydrate based anti-thrombotic agents.

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Anti-Infective AgentsAntibodies, MonoclonalBacterial VaccinesCarbohydratesClinical Trials as TopicDrug Delivery SystemsFibrinolytic AgentsGlycosaminoglycansGlycoside HydrolasesGlycosyltransferasesHumansLectinsPolysaccharides, BacterialJournal ArticleReview

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BibTeXRIS

Helen M I Osborn, Philip G Evans, Natasha Gemmell, Sadie D Osborne. 2004. Carbohydrate-based therapeutics.. https://doi.org/10.1211/0022357023619

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