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PubMed · 15239079

Acetaminophen misconceptions.

Barry H Rumack
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Abstract

Examination of the pharmacokinetics of acetaminophen can decrease misconceptions involved in clinical evaluation. Enzyme patterns and acetaminophen levels must be related to time and known metabolic phenomena. A careful look at ethanol and nutrition, especially fasting demonstrates that therapeutic doses of acetaminophen do not place patients at a greater risk in either of these instances. An overdose of acetaminophen in a chronic alcohol abuser may result in more severe hepatotoxicity than in the nonalcoholic. CYP2E1 and glutathione must be evaluated simultaneously rather than in isolation. Glucuronidation capacity in humans is not a factor except in massively overdosed patients.

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AcetaminophenAlcohol DrinkingAnalgesics, Non-NarcoticDrug InteractionsHumansLiverPhenobarbitalPhenytoinJournal ArticleReview

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Barry H Rumack. 2004. Acetaminophen misconceptions.. https://doi.org/10.1002/hep.20300

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