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Current status and future prospects of array-based comparative genomic hybridisation.

Antoine M Snijders·Daniel Pinkel·Donna G Albertson
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Abstract

The majority of human cancers as well as many developmental abnormalities harbour chromosomal imbalances, many of which result in the gain and/or loss of genomic material. Conventional comparative genomic hybridisation (CGH) has been used extensively to map DNA copy number changes to chromosomal positions. The introduction of microarray CGH provided a powerful tool to precisely detect and quantify genomic aberrations and map these directly onto the sequence of the human genome. In the past several years, a number of different approaches towards array-based CGH have been undertaken. This paper reviews these approaches and presents some of the recently-developed applications of this new technology in both research and clinical settings.

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Chromosome AberrationsDNA, NeoplasmGene DosageGenetic MarkersHumansIn Situ Hybridization, FluorescenceNeoplasmsNucleic Acid HybridizationOligonucleotide Array Sequence AnalysisComparative StudyJournal ArticleReview

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Antoine M Snijders, Daniel Pinkel, Donna G Albertson. 2003. Current status and future prospects of array-based comparative genomic hybridisation.. https://doi.org/10.1093/bfgp%2F2.1.37

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