AN-9 (Titan).

Erole Hobdy; John Murren

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PubMed · 15242252

AN-9 (Titan).

Erole Hobdy·John Murren

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Abstract

Titan is developing AN-9 for the potential treatment of various cancers. AN-9 is a histone deacetylase inhibitor analog of butyric acid that causes apoptosis of cancer cells through signaling cellular differentiation. In March 2001, a phase I/II study involving patients with liver tumors was initiated. By November 2001, enrollment had been completed in a second phase II study of refractory non-small-cell lung cancer (NSCLC). In June 2003, Titan began enrollment for a phase IIb trial of AN-9 in combination with docetaxel in patients with NSCLC.

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Animals Antineoplastic Agents Butyrates Clinical Trials, Phase I as Topic Clinical Trials, Phase II as Topic Drugs, Investigational Humans Neoplasms Journal Article Review

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Erole Hobdy, John Murren. 2004. AN-9 (Titan).. https://pubmed.ncbi.nlm.nih.gov/15242252/

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