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PubMed · 15242722

Sulfonamide hypersensitivity.

Christopher G Slatore·Stephen A Tilles
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Abstract

Sulfonamide antibiotics can result in a wide variety of hypersensitivity reactions. No validated diagnostic tests are available for sulfonamide reactions; therefore, clinicians must rely on the combination of a careful patient history, review of medical records, and a sound knowledge base regarding the common clinical manifestations of sulfonamide hypersensitivity reactions. Although HIV-infected individuals have a high risk for hypersensitivity reactions to sulfamethoxazole, readministering the drug can usually be performed safely by using a desensitization protocol. Sulfonamide-containing medications that are not antibiotics also have the capacity for causing hypersensitivity reactions. Whether the sulfa moiety confers a risk of cross-reaction is controversial. The preponderance of available evidence suggests that sulfonamide antibiotics probably do not cross-react with sulfonamide nonantibiotics.

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Cross ReactionsDesensitization, ImmunologicDiagnosis, DifferentialDrug HypersensitivityHIV InfectionsHumansSulfonamidesJournal ArticleReview

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BibTeXRIS

Christopher G Slatore, Stephen A Tilles. 2004. Sulfonamide hypersensitivity.. https://doi.org/10.1016/j.iac.2004.03.011

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