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PubMed · 15246320

Intravascular schistosomes and complement.

Patrick J Skelly
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Abstract

Schistosomes are exposed to a variety of immunological effectors, such as host complement, in the bloodstream of their definitive hosts. The parasites are reported to possess a plethora of regulatory proteins, including molecules acquired from the host, which impede the complement cascade. Evidence for the presence of a surface C2-binding protein, a C3-binding protein and a C8- and C9-binding protein has been reported. In addition, a surface Fc receptor might bind immunoglobulin and limit its ability to fix complement. However, the actual protective role of these proteins in vivo remains unresolved.

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AnimalsComplement ActivationComplement Pathway, AlternativeComplement Pathway, ClassicalComplement Pathway, Mannose-Binding LectinHumansReceptors, ComplementSchistosomaSchistosomiasisJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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Patrick J Skelly. 2004. Intravascular schistosomes and complement.. https://doi.org/10.1016/j.pt.2004.05.007

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