T cell replicative senescence: pleiotropic effects on human aging.

Rita B Effros

doi:10.1196/annals.1297.022

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T cell replicative senescence: pleiotropic effects on human aging.

Rita B Effros

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Abstract

Long-term culture studies using CD8 T cells, the immune cells responsible for control of viral infection, have identified the major features of replicative senescence. Aging is associated with increased proportions of CD8 T cells with similar characteristics, such as absence of expression of the CD28 costimulatory molecule and reduced antiviral effector functions. Proinflammatory cytokines produced by senescent CD8 T cells also may exert pleiotropic suppressive effects on overall immune function and bone homeostasis. Thus, modulation of T cell replicative senescence may provide a comprehensive therapeutic strategy to prevent multiple age-associated pathologies.

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Aging CD28 Antigens CD8-Positive T-Lymphocytes Cellular Senescence Homeostasis Humans Immune System T-Lymphocytes Journal Article Research Support, Non-U.S. Gov't Review

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Rita B Effros. 2004. T cell replicative senescence: pleiotropic effects on human aging.. https://doi.org/10.1196/annals.1297.022

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