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PubMed · 15247471

Exploiting tolerance processes in transplantation.

Herman Waldmann·Stephen Cobbold
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Abstract

The full potential of organ transplantation has not yet been realized because of the hazards associated with the long-term use of immunosuppressive drugs. Modern research into mechanisms of immune tolerance offers the promise of reprogramming the immune system, so as to harness the body's natural tolerance mechanisms in the service of graft acceptance. This would allow the minimization of immunosuppressive treatment and offers the prospect of eventually weaning transplant recipients off their drugs.

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AnimalsBiomarkersBone Marrow TransplantationGraft Enhancement, ImmunologicGraft RejectionGraft SurvivalHumansImmunosuppressive AgentsLymphocyte DepletionT-LymphocytesTransplantation ChimeraTransplantation ConditioningTransplantation ImmunologyTransplantation ToleranceJournal Article

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Herman Waldmann, Stephen Cobbold. 2004-07-09. Exploiting tolerance processes in transplantation.. https://doi.org/10.1126/science.1099538

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