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PubMed · 15251137

Regulatory T cells.

Claire Thompson·Fiona Powrie
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Abstract

Regulatory T (TR) cells are a subset of T cells that function to control immune responses. Different populations of TR cells have been described, including thymically derived CD4(+)CD25+ TR cells and Tr1 cells induced in the periphery through exposure to antigen. A transcription factor, Foxp3, has been identified that is essential for CD4(+)CD25+ TR cell development and function. There is now evidence that transforming growth factor-beta might play a role in this pathway. CD4(+)CD25+ TR cells proliferate extensively in vivo in an antigen-specific manner, and can respond to both self and foreign peptides. By suppressing excessive immune responses, TR cells play a key role in the maintenance of self-tolerance, thus preventing autoimmune disease, as well as inhibiting harmful inflammatory diseases such as asthma and inflammatory bowel disease.

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AnimalsAntigens, CDAntigens, DifferentiationCD4-Positive T-LymphocytesCTLA-4 AntigenHumansInterleukin-10Lymphocyte ActivationReceptors, Interleukin-2Transforming Growth Factor betaTransforming Growth Factor beta1Journal ArticleResearch Support, Non-U.S. Gov'tReview

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Claire Thompson, Fiona Powrie. 2004. Regulatory T cells.. https://doi.org/10.1016/j.coph.2004.05.001

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