Innate immunity in aging: impact on macrophage function.

Julie Plowden; Mary Renshaw-Hoelscher; Carrie Engleman; Jacqueline Katz; Suryaprakash Sambhara

doi:10.1111/j.1474-9728.2004.00102.x

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Innate immunity in aging: impact on macrophage function.

Julie Plowden·Mary Renshaw-Hoelscher·Carrie Engleman·Jacqueline Katz·Suryaprakash Sambhara

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Abstract

Innate and adaptive immune functions decline with age, leading to increased susceptibility to infectious diseases and cancer, and reduced responses to preventive vaccination in the elderly population. Macrophages function as 'pathogen sensors' and play an important role in the initiation of inflammatory responses, elimination of pathogens, manipulation of the adaptive immune response and reparation of damaged tissue. In this paper, we review the literature addressing the impact of aging on the macrophage population.

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Aging Animals Antimicrobial Cationic Peptides Cell Lineage Chemokines Cytokines Humans Immunity, Innate Langerhans Cells Macrophages Membrane Glycoproteins Phagocytosis Receptors, Cell Surface Toll-Like Receptors Wound Healing Journal Article Review

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Julie Plowden, Mary Renshaw-Hoelscher, Carrie Engleman, Jacqueline Katz, Suryaprakash Sambhara. 2004. Innate immunity in aging: impact on macrophage function.. https://doi.org/10.1111/j.1474-9728.2004.00102.x

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