CAR: detailing new models.

Bryan Goodwin; John T Moore

doi:10.1016/j.tips.2004.06.007

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CAR: detailing new models.

Bryan Goodwin·John T Moore

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Abstract

Functional analysis has broadened our understanding of the physiological roles of the two related nuclear receptors pregnane X receptor (PXR; NR1I2) and constitutive androstane receptor (CAR; NR1I3). Initial research focused on the role of these two receptors in xenobiotic detoxification and, more recently, additional functional roles for CAR have been identified. Specifically, CAR activity has been shown to ameliorate the effects of hyperbilirubinemia, caloric restriction and toxic bile acids. Thus, the physiological role of CAR has broadened to include responses to metabolic and nutritional stress. These data highlight potential new opportunities in targeting CAR for drug discovery.

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Animals Cholestasis Constitutive Androstane Receptor Humans Hyperbilirubinemia Obesity Pregnane X Receptor Receptors, Cytoplasmic and Nuclear Receptors, Steroid Transcription Factors Journal Article Review

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Bryan Goodwin, John T Moore. 2004. CAR: detailing new models.. https://doi.org/10.1016/j.tips.2004.06.007

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