Reverse fluorous solid-phase extraction: a new technique for rapid separation of fluorous compounds.

Masato Matsugi; Dennis P Curran

doi:10.1021/ol049040o

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PubMed · 15281752

Reverse fluorous solid-phase extraction: a new technique for rapid separation of fluorous compounds.

Masato Matsugi·Dennis P Curran

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Abstract

Fluorous-tagged compounds can rapidly be separated from organic (non-tagged) compounds by the new separation technique of reverse fluorous solid-phase extraction (r-fspe). In a reversal of the roles of solid and liquid phases in standard fluorous spe, a mixture is charged to a polar solid phase (standard silica gel) and then eluted with a fluorous solvent or solvent mixture. The organic components of the mixture are retained, while the fluorous components pass. [structure: see text]

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Chromatography, Gel Fluorine Compounds Organic Chemicals Silica Gel Silicon Dioxide Solvents Journal Article Research Support, U.S. Gov't, P.H.S.

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Masato Matsugi, Dennis P Curran. 2004-08-05. Reverse fluorous solid-phase extraction: a new technique for rapid separation of fluorous compounds.. https://doi.org/10.1021/ol049040o

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