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Long-term silicone central venous catheters impregnated with minocycline and rifampin decrease rates of catheter-related bloodstream infection in cancer patients: a prospective randomized clinical trial.

Hend Hanna·Robert Benjamin·Ioannis Chatzinikolaou·Badie Alakech·Deborah Richardson·Paul Mansfield·Tanya Dvorak·Mark F Munsell·Rabih Darouiche·Hagop Kantarjian·Issam Raad
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Abstract

PURPOSE: To evaluate the efficacy of long-term nontunneled silicone catheters impregnated with minocycline and rifampin (M-R) in reducing catheter-related bloodstream infections. PATIENTS AND METHODS: This prospective, randomized, double-blind clinical trial was conducted at M.D. Anderson Cancer Center, a tertiary care hospital in Houston, TX. All patients in the trial had a malignancy. RESULTS: Between September 1999 and May 2002, 356 assessable catheters were used: 182 M-R and 174 nonimpregnated. The patients' characteristics were comparable between the two study groups. The mean (+/- standard deviation) duration of catheterization with M-R catheters was comparable to that of nonimpregnated catheters (66.21 +/- 30.88 v 63.01 +/- 30.80 days). A total of 17 catheter-related bloodstream infections occurred during the course of the study. Three were associated with the use of M-R catheters and 14 were associated with the nonimpregnated catheters, with a rate of catheter-related bloodstream infection of 0.25 and 1.28/1,000 catheter-days, respectively (P = .003). Gram-positive cocci accounted for the majority of the organisms causing the infections. There were no allergic reactions associated with M-R catheters. CONCLUSION: Long-term nontunneled central venous catheters impregnated with minocycline and rifampin are efficacious and safe in reducing catheter-related bloodstream infections in cancer patients.

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Anti-Bacterial AgentsBacteremiaCatheterization, Central VenousCatheters, IndwellingDouble-Blind MethodFemaleHumansMaleMiddle AgedMinocyclineNeoplasmsProspective StudiesRifampinSiliconesClinical TrialJournal ArticleRandomized Controlled TrialResearch Support, Non-U.S. Gov't

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Hend Hanna, Robert Benjamin, Ioannis Chatzinikolaou, Badie Alakech, Deborah Richardson, Paul Mansfield, Tanya Dvorak, Mark F Munsell, Rabih Darouiche, Hagop Kantarjian, Issam Raad. 2004-08-01. Long-term silicone central venous catheters impregnated with minocycline and rifampin decrease rates of catheter-related bloodstream infection in cancer patients: a prospective randomized clinical trial.. https://doi.org/10.1200/jco.2004.04.124

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