Notch and T cell malignancy.

Patrick A Zweidler-McKay; Warren S Pear

doi:10.1016/j.semcancer.2004.04.012

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Notch and T cell malignancy.

Patrick A Zweidler-McKay·Warren S Pear

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Abstract

Notch signaling is required for normal T cell development. However, Notch expression must be precisely regulated as constitutive Notch signaling leads to T cell lymphomas. Recent evidence has provided insights into potential mechanisms of Notch-mediated lymphomagenesis and its relationship to T cell development. The evidence suggests that Notch likely interacts with several important cellular pathways and can cooperate with other oncogenes during lymphomagenesis. In particular, Notch appears to modulate pre-TCR signaling, inhibit the E2A pathway, and in murine leukemia models, frequently cooperates with Myc, E2A-PBX and dominant negative Ikaros dysregulation. This review will present current knowledge in these areas and explore theories on Notch-mediated T cell lymphomagenesis.

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Animals Humans Lymphoma, T-Cell Membrane Proteins Mice Receptors, Notch Signal Transduction Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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Patrick A Zweidler-McKay, Warren S Pear. 2004. Notch and T cell malignancy.. https://doi.org/10.1016/j.semcancer.2004.04.012

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