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PubMed · 15289650

(Pro)Insulin processing: a historical perspective.

Howard W Davidson
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Abstract

Insulin, the major secreted product of the beta-cells of the islets of Langerhans, is initially synthesized as a precursor (preproinsulin), from which the mature hormone is excised by a series of proteolytic cleavages. This review provides a personal narrative of some of the key research projects leading to the identification of the central processing enzymes as proprotein convertase 1, proprotein convertase 2, and carboxypeptidase E. It also discusses the central roles of the intragranular environment and chaperone-like proteins in modulating processing activity.

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Amino Acid SequenceAnimalsCarboxypeptidase HHumansInsulinInsulin-Secreting CellsModels, BiologicalMolecular ChaperonesMolecular Sequence DataProinsulinProprotein Convertase 1Proprotein Convertase 2Protein Structure, TertiaryTrypsinJournal ArticleReview

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Howard W Davidson. 2004. (Pro)Insulin processing: a historical perspective.. https://doi.org/10.1385/cbb%3A40%3A3%3A143

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