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Topotecan-induced bronchiolitis.

Colin C Edgerton·Matthew Gilman·Bernard J Roth
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Abstract

Topotecan HCl is an antitumor drug exhibiting topoisomerase 1-inhibitory activity. Topotecan is used in the treatment of metastatic carcinoma of the ovary and as second-line treatment of small-cell lung cancer. Reported dose-limiting adverse reactions to topotecan are primarily hematologic in nature. To date, only one other case of lung toxicity in a patient taking topotecan has been reported. The authors describe the development of obliterative bronchiolitis, as evidenced by radiographic and pulmonary function testing abnormalities, in a 61-year-old woman who presented with dyspnea, and who was receiving topotecan for peritoneal carcinomatosis.

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Antineoplastic AgentsBronchiolitisCarcinomaEnzyme InhibitorsFemaleHumansMiddle AgedPeritoneal NeoplasmsTopoisomerase I InhibitorsTopotecanCase ReportsJournal Article

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Colin C Edgerton, Matthew Gilman, Bernard J Roth. 2004. Topotecan-induced bronchiolitis.. https://doi.org/10.1097/00007611-200407000-00018

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