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PubMed · 15312123

Herpes simplex virus-based vectors.

Robin Lachmann
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Abstract

Herpes simplex virus (HSV)-based vectors have primarily been developed for neuronal gene delivery, taking advantage of the virus' natural neurotropism. Two types of vector are available: replication defective viruses, whose cytotoxicity has been abolished by deleting viral gene products, and amplicon vectors, which are plasmids packaged into HSV particles with the aid of a helper virus. In this review I discuss how the cytotoxicity of the wild-type virus has been abolished, the progress which has been made toward defining promoter elements capable of directing long-term transgene expression form the latent viral genome and some of the potential clinical uses of these versatile vectors.

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Gene TargetingGene Transfer TechniquesGenetic TherapyGenetic VectorsHumansNervous System DiseasesPlasmidsSimplexvirusJournal ArticleReview

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BibTeXRIS

Robin Lachmann. 2004. Herpes simplex virus-based vectors.. https://doi.org/10.1111/j.0959-9673.2004.00383.x

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