Genomic segmental polymorphisms in inbred mouse strains.

Jiangzhen Li; Tao Jiang; Jian-Hua Mao; Allan Balmain; Leif Peterson; Charles Harris; Pulivarthi H Rao; Paul Havlak; Richard Gibbs; Wei-Wen Cai

doi:10.1038/ng1417

PubMed · 15322544

Genomic segmental polymorphisms in inbred mouse strains.

Jiangzhen Li·Tao Jiang·Jian-Hua Mao·Allan Balmain·Leif Peterson·Charles Harris·Pulivarthi H Rao·Paul Havlak·Richard Gibbs·Wei-Wen Cai

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Abstract

By analyzing genomic copy-number differences using high-resolution mouse whole-genome BAC arrays, we uncover substantial differences in regional DNA content between inbred strains of mice. The identification of these apparently common segmental polymorphisms suggests that these differences can contribute to genetic variability and pathologic susceptibility.

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Animals Base Sequence Chromosomes, Artificial, Bacterial Gene Dosage In Situ Hybridization, Fluorescence Mice Mice, Inbred Strains Polymorphism, Genetic Journal Article Research Support, U.S. Gov't, Non-P.H.S.

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Jiangzhen Li, Tao Jiang, Jian-Hua Mao, Allan Balmain, Leif Peterson, Charles Harris, Pulivarthi H Rao, Paul Havlak, Richard Gibbs, Wei-Wen Cai. 2004-08-22. Genomic segmental polymorphisms in inbred mouse strains.. https://doi.org/10.1038/ng1417

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