SRCircumventing imatinib resistance.

Michael W N Deininger; Brian J Druker

doi:10.1016/j.ccr.2004.08.006

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SRCircumventing imatinib resistance.

Michael W N Deininger·Brian J Druker

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Abstract

The ABL inhibitor imatinib is a highly effective therapy for patients with chronic myeloid leukemia. Relapses after an initial response have been observed in some patients, and mutations of the BCR-ABL gene are the most common mechanism driving these relapses. Alternative ABL inhibitors have been identified that inhibit most of the common BCR-ABL mutations, and one has entered clinical trials. The structural basis for these results has yielded significant insights into the mechanism of action of these compounds, mechanisms of resistance, and their ability to inhibit the BCR-ABL mutants. These studies demonstrate the importance and impact of conducting scientific studies as part of clinical trials.

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Antineoplastic Agents Benzamides Clinical Trials as Topic Drug Resistance, Neoplasm Enzyme Inhibitors Fusion Proteins, bcr-abl Humans Imatinib Mesylate Leukemia, Myelogenous, Chronic, BCR-ABL Positive Models, Molecular Piperazines Protein Conformation Pyrimidines Journal Article

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Michael W N Deininger, Brian J Druker. 2004. SRCircumventing imatinib resistance.. https://doi.org/10.1016/j.ccr.2004.08.006

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