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Analysis of KIT (CD117) expression in gallbladder carcinomas by tissue microarray.

C Langner·M Lemmerer·P Kornprat
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Abstract

AIMS: KIT (CD117) is a transmembrane tyrosinase-kinase receptor which has been related to cell proliferation, differentiation, adhesion and control of apoptosis. If present, KIT may provide a suitable target for tumour therapy. In this study, we report the presence of KIT in primary and metastatic gallbladder carcinomas. METHODS: Formalin-fixed and paraffin-embedded specimens of 57 primary gallbladder carcinomas and 18 corresponding metastases were stained using a tissue microarray technique and two different antibodies. RESULTS: Only three tumours stained for KIT. With a polyclonal antibody only one well differentiated papillary adenocarcinoma was immunoreactive. With a monoclonal antibody two additional poorly differentiated tubular adenocarcinoma showed weak and focal immunostaining. CONCLUSIONS: KIT immunoreactivity is infrequent in gallbladder carcinoma. Thus, routine screening of tumour tissues for KIT by immunohistochemistry appears to be cost-ineffective and cannot be recommended. Moreover, the lack of substantial KIT immunoreactivity in both primary and metastatic gallbladder carcinoma tissues does not provide a rationale to investigate imatinib mesylate therapy in clinical trials including patients with advanced disease.

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AdenocarcinomaAdultAgedAged, 80 and overBiomarkers, TumorBiopsy, NeedleCase-Control StudiesFemaleGallbladder NeoplasmsHumansImmunohistochemistryMaleMiddle AgedNeoplasm InvasivenessParaffin EmbeddingPrognosisProtein Array AnalysisProto-Oncogene Proteins c-kitRisk AssessmentSampling StudiesSensitivity and SpecificityComparative StudyJournal Article

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C Langner, M Lemmerer, P Kornprat. 2004. Analysis of KIT (CD117) expression in gallbladder carcinomas by tissue microarray.. https://doi.org/10.1016/j.ejso.2004.05.002

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