Apoptosis and genomic instability.

Boris Zhivotovsky; Guido Kroemer

doi:10.1038/nrm1443

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Apoptosis and genomic instability.

Boris Zhivotovsky·Guido Kroemer

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Abstract

Genomic instability is intrinsically linked to significant alterations in apoptosis control. Chromosomal and microsatellite instability can cause the inactivation of pro-apoptotic pathways. In addition, the inhibition of apoptosis itself can be permissive for the survival and ongoing division of cells that have failed to repair DNA double-strand breaks, experience telomere dysfunction or are in an abnormal polyploid state. Furthermore, DNA-repair proteins can regulate apoptosis. So, genomic instability and apoptosis are intimately linked phenomena, with important implications for the pathophysiology of cancer.

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Animals Apoptosis Cell Cycle Cell Survival Cellular Senescence DNA Damage DNA Repair Genomic Instability Humans Ploidies Signal Transduction Telomere Tumor Suppressor Protein p53 Journal Article Research Support, Non-U.S. Gov't Review

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Boris Zhivotovsky, Guido Kroemer. 2004. Apoptosis and genomic instability.. https://doi.org/10.1038/nrm1443

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