Structure/function relationships of CREB/ATF proteins.

Abstract

Signal-transduction pathways converge ultimately at the level of transcriptional activation to produce specific patterns of gene expression in response to environmental stimuli. The initiation of transcription mediated by these signaling pathways is regulated by the coordinate expression and/or activation of specific transcription factors that bind to the control regions of genes. Specific insights into the mechanisms underlying transcriptional activation have recently arisen from studies of the structure and functions of these transcription factors. The CREB/ATF family of transcriptional transactivating proteins has only recently been discovered and appears to provide a link between the regulation of gene expression in response to activators of cellular signaling pathways and the regulation of gene expression by viral transactivating proteins. In addition, these proteins may be involved in the normal regulation of growth and differentiation. Understanding the nature and importance of the role(s) of these proteins in the normal regulation of growth and differentiation will have profound influences on the understanding of the aberrant regulation of these processes during oncogenesis.