PubMed · 15341380
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Lynn Hiltz. Advocate.. https://pubmed.ncbi.nlm.nih.gov/15341380/
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Immunological alterations in psychiatric disorders have gained increasing scientific attention throughout the last decade. Particularly in two disorders, major depression and schizophrenia, some substantial findings have been reported. Although such results stand not uncontradicted, they nevertheless stimulate current research into the neurobiological underpinnings of these diseases. In this review, immunological dysfunctions in major depression and schizophrenia are described in detail, together with studies on posttraumatic stress disorders, panic- and obsessive-compulsive disorders. Possible future research directions are delineated.
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In a prospective cohort study of 142 outpatients with advanced heart failure followed for a mean of 3 years, 29% of subjects with a depression diagnosis at baseline were significantly more likely to experience the combined end point of death or transplantation (hazard ratio 2.54, 95% confidence interval 1.16 to 5.55). After adjustment for a range of sociodemographic and clinical characteristics, patients with depressive disorders were still significantly more likely to reach the combined end point (hazard ratio 2.41, 95% confidence interval 1.24 to 4.68). Depressed patients also had more heart failure related hospitalizations (1.5 +/- 1.8 vs 0.6 +/- 1.4, p = 0.04) and clinic visits (2.4 +/- 1.7 vs 1.7 +/- 1.8, p = 0.04) over the first year of follow-up.