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PubMed · 15342013

TAP genes and immunity.

James McCluskey·Jamie Rossjohn·Anthony W Purcell
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Abstract

The transporter associated with antigen processing (TAP) is a member of the ATP-binding cassette transporter family that specializes in delivering cytosolic peptides to class I molecules in the endoplasmic reticulum. The TAP is a major target of genetic alteration in tumours and disruption by viral inhibitors. In some species, TAP genes have co-evolved with MHC class I molecules to deliver peptides that are customised for particular alleles. In humans, MHC class I polymorphism determines the level of tapasin-mediated association with TAP and subsequent peptide optimisation within the peptide-loading complex (PLC). MHC class I molecules that still load peptides without complexing to the TAP might be more resistant to viral interference of the PLC and less sensitive to competition for TAP by other class I allotypes.

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ATP-Binding Cassette TransportersAmino Acid SequenceAnimalsAntiportersHistocompatibility Antigens Class IHumansImmunoglobulinsMembrane Transport ProteinsMolecular Sequence DataPolymorphism, GeneticVirusesJournal ArticleReview

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James McCluskey, Jamie Rossjohn, Anthony W Purcell. 2004. TAP genes and immunity.. https://doi.org/10.1016/j.coi.2004.07.016

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