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Various immunization protocols for an acute motor axonal neuropathy rabbit model compared.

Keiichiro Susuki·Yukihiro Nishimoto·Michiaki Koga·Takahide Nagashima·Izumi Mori·Koichi Hirata·Nobuhiro Yuki
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Abstract

Various ganglioside immunization protocols were examined to refine the procedure for establishing an animal model of acute motor axonal neuropathy. The most effective was subcutaneous injection of an emulsion of 2.5mg of bovine brain ganglioside mixtures, keyhole lympet hemocyanin, and complete Freund's adjuvant to Japanese white rabbits, repeated at 3-week intervals. Under that protocol, all the rabbits developed marked flaccid paralysis associated with plasma anti-GM1 IgG antibody. This acute motor axonal neuropathy rabbit model also could be reproduced by the use of incomplete Freund's adjuvant, methylated bovine serum albumin, and New Zealand white rabbits. These results provide useful information for the confirmation of and further research on the model.

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Acute DiseaseAnimalsAutoimmune Diseases of the Nervous SystemAxonsBCG VaccineCattleDose-Response Relationship, DrugFemaleGangliosidesGangliosidosis, GM1HemocyaninsImmunizationMaleMotor NeuronsRabbitsRatsRats, Inbred LewSerum Albumin, BovineComparative StudyJournal ArticleResearch Support, Non-U.S. Gov't

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Keiichiro Susuki, Yukihiro Nishimoto, Michiaki Koga, Takahide Nagashima, Izumi Mori, Koichi Hirata, Nobuhiro Yuki. 2004-09-16. Various immunization protocols for an acute motor axonal neuropathy rabbit model compared.. https://doi.org/10.1016/j.neulet.2004.06.059

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