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PubMed · 15342607

Extensive genomic polymorphism within Mycobacterium avium.

Makeda Semret·Gary Zhai·Serge Mostowy·Cynthia Cleto·David Alexander·Gerard Cangelosi·Debby Cousins·Desmond M Collins·Dick van Soolingen·Marcel A Behr
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Abstract

We have initiated comparative genomic analysis of Mycobacterium avium subspecies by DNA microarray, uncovering 14 large sequence polymorphisms (LSPs) comprising over 700 kb that distinguish M. avium subsp. avium from M. avium subsp. paratuberculosis. Genes predicted to encode metabolic pathways were overrepresented in the LSPs, and analysis revealed a polymorphism within the mycobactin biosynthesis operon that potentially explains the in vitro mycobactin dependence of M. avium subsp. paratuberculosis.

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Chromosomes, BacterialDNA, BacterialGenes, BacterialGenome, BacterialMycobacterium aviumMycobacterium avium subsp. paratuberculosisOligonucleotide Array Sequence AnalysisOxazolesPolymorphism, GeneticComparative StudyJournal ArticleResearch Support, Non-U.S. Gov't

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Makeda Semret, Gary Zhai, Serge Mostowy, Cynthia Cleto, David Alexander, Gerard Cangelosi, Debby Cousins, Desmond M Collins, Dick van Soolingen, Marcel A Behr. 2004. Extensive genomic polymorphism within Mycobacterium avium.. https://doi.org/10.1128/jb.186.18.6332-6334.2004

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