[Primary care for GEDR].

Hiroshi Takeda

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PubMed · 15344540

[Primary care for GEDR].

Hiroshi Takeda

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Abstract

Current approach for the treatment of gastroesopageal reflux disease (GERD) was reviewed. The most effective treatment of erosive esophagitis or symptomatic GERD is to reduce gastric acid secretion with either an H2 receptor antagonists (H2RA) or a proton pump inhibitor (PPI). The PPI lead to more rapid healing and symptom relief than H2RA. Despite treatment with PPI, some patients with GERD continue to have symptoms or endoscopic evidence of esophagitis. Nocturnal acid breakthrough may be one of the mechanisms responsible for the refractory GERD. There are two approaches to the initial medical treatment of gastroesophageal reflux disease ('step down' therapy or 'step up' approach). Although there are arguments in favour of both approaches, the former is considered to be preferable these days.

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2-Pyridinylmethylsulfinylbenzimidazoles Benzimidazoles Circadian Rhythm Drug Therapy, Combination Enzyme Inhibitors Gastric Acid Gastroesophageal Reflux Histamine H2 Antagonists Humans Lansoprazole Laparoscopy Omeprazole Proton Pump Inhibitors Rabeprazole Journal Article Review

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Hiroshi Takeda. 2004. [Primary care for GEDR].. https://pubmed.ncbi.nlm.nih.gov/15344540/

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Pantoprazole 40 mg is as effective as esomeprazole 40 mg to relieve symptoms of gastroesophageal reflux disease after 4 weeks of treatment and superior regarding the prevention of symptomatic relapse.

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PubMed2007

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2-Pyridinylmethylsulfinylbenzimidazoles↗

PubMed2007

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2-Pyridinylmethylsulfinylbenzimidazoles↗