CD23 expression in aged rats.

V Chavez; M Parreira Soares; H Bazin

doi:10.1159/000236141

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CD23 expression in aged rats.

V Chavez·M Parreira Soares·H Bazin

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Abstract

CD23 is considered as an activation marker. Its expression on lymphocytes was studied during aging by using 1- to 142-week-old rats. Before analysis, all animals were injected with monoclonal IgE, in order to detect their full expression of CD23 molecules on their lymphocyte surface membranes. In elderly rats, a decrease was observed in the percentages of CD23+ lymphocytes from mesenteric lymph nodes, spleen, Peyer's patches and peripheral blood. In addition, these lymphocytes expressed significantly fewer CD23 molecules per cell. Almost all CD23+ cells belonged to the B lineage and were bearing both IgM and IgD on their membranes. It is suggested that a decrease in the number of both IgM+IgD+CD23+ lymphocytes and CD23 molecules per cell may contribute to immune deficiency in the elderly.

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Aging Analysis of Variance Animals Antigens, Differentiation, B-Lymphocyte Female Gene Expression Immunoglobulin E Immunoglobulin M Immunophenotyping Lymphocytes Male Rats Rats, Inbred Strains Receptors, Fc Receptors, IgE Journal Article Research Support, Non-U.S. Gov't

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V Chavez, M Parreira Soares, H Bazin. 1992. CD23 expression in aged rats.. https://doi.org/10.1159/000236141

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