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PubMed · 15355426

Will the new cytogenetics replace the old cytogenetics?

M Salman·S C Jhanwar·H Ostrer
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Abstract

With the advent of array-based comparative genomic hybridization technology, the analog cytogenetic analysis that has been used for the past 100 years could be replaced by the quantitative, microarray-based molecular analysis. Major advantages of the new array-based cytogenetic technologies are the high resolution and the high throughput. This technology is the first to offer an autonomous whole-chromosome analysis in one hybridization reaction for the detection of submicroscopic gains/losses. However, as with any new technology, it needs to be validated with regard to its performance in various applications (e.g. clinical genetic testing and cancer applications), comparative cost, and the data interpretation.

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Chromosome AberrationsCytogeneticsHumansNucleic Acid HybridizationJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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BibTeXRIS

M Salman, S C Jhanwar, H Ostrer. 2004. Will the new cytogenetics replace the old cytogenetics?. https://doi.org/10.1111/j.1399-0004.2004.00316.x

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