Gene-regulatory interactions in neural crest evolution and development.

Daniel Meulemans; Marianne Bronner-Fraser

doi:10.1016/j.devcel.2004.08.007

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Gene-regulatory interactions in neural crest evolution and development.

Daniel Meulemans·Marianne Bronner-Fraser

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Abstract

In this review, we outline the gene-regulatory interactions driving neural crest development and compare these to a hypothetical network operating in the embryonic ectoderm of the cephalochordate amphioxus. While the early stages of ectodermal patterning appear conserved between amphioxus and vertebrates, later activation of neural crest-specific factors at the neural plate border appears to be a vertebrate novelty. This difference may reflect co-option of genetic pathways which conferred novel properties upon the evolving vertebrate neural plate border, potentiating the evolution of definitive neural crest.

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Animals Down-Regulation Ectoderm Gene Expression Regulation, Developmental Invertebrates Models, Biological Neural Crest Phenotype Signal Transduction NASA Discipline Evolutionary Biology Non-NASA Center Journal Article Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Review

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Daniel Meulemans, Marianne Bronner-Fraser. 2004. Gene-regulatory interactions in neural crest evolution and development.. https://doi.org/10.1016/j.devcel.2004.08.007

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