Can we really learn from model pathogens?

Arno Müllbacher; Matthias Regner; Yang Wang; Eva Lee; Mario Lobigs; Markus Simon

doi:10.1016/j.it.2004.08.004

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Can we really learn from model pathogens?

Arno Müllbacher·Matthias Regner·Yang Wang·Eva Lee·Mario Lobigs·Markus Simon

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Abstract

Cytolytic T (Tc) lymphocytes are the first order response of the adaptive immune system in the recovery from primary viral infections. These effector cells execute their function either by direct cytotoxicity through the Fas or perforin pathway and/or by the release of cytokines that either directly or indirectly exert antiviral activity. Mice respond to infection by closely related viruses with a vigorous Tc response, which is characterized by extensive crossreactivity on target cells infected with these viruses. However, the action of these cells can be beneficial, detrimental or neutral. From our current state of knowledge, no generalizations as to protective or detrimental effects of cytolytic effector functions in recovery from virus infections can be made. Thus, virus-host immune interactions have to be assessed individually and cannot be generalized.

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Animals Cytotoxicity, Immunologic Disease Models, Animal Flaviviridae Infections Flavivirus Host-Parasite Interactions Mice Models, Immunological Orthopoxvirus Poxviridae Infections Signal Transduction T-Lymphocytes, Cytotoxic Comparative Study Journal Article Review

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Arno Müllbacher, Matthias Regner, Yang Wang, Eva Lee, Mario Lobigs, Markus Simon. 2004. Can we really learn from model pathogens?. https://doi.org/10.1016/j.it.2004.08.004

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