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The centrosome in higher organisms: structure, composition, and duplication.

Young Ou·J B Rattner
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Abstract

The centrosome found in higher organisms is an organelle with a complex and dynamic architecture and composition. This organelle not only functions as a microtubule-organizing center, but also is integrated with or impacts a number of cellular processes. Defects associated with this organelle have been linked to a variety of human diseases including several forms of cancer. Here we review the emerging picture of how the structure, composition, duplication, and function of the centrosome found in higher organisms are interrelated.

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A Kinase Anchor ProteinsAdaptor Proteins, Signal TransducingAnimalsAntigensCell DivisionCell NucleusCentrosomeChromosomesChromosomes, MammalianCytoskeletal ProteinsHumansMicrotubule-Associated ProteinsMicrotubulesMolecular Motor ProteinsPhosphoprotein PhosphatasesProtein KinasesJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Young Ou, J B Rattner. 2004. The centrosome in higher organisms: structure, composition, and duplication.. https://doi.org/10.1016/s0074-7696(04)38003-4

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