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Localised astroglial dysfunction disrupts high-frequency EEG rhythms.

J O Willoughby·L Mackenzie·K J Pope·M Broberg·M Nilsson
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Abstract

We used cerebral cortex injections of fluorocitrate to determine if selective astrocytic disturbances affect the electroencephalogram (EEG). Rats were halothane-anaesthetized and 0.8 nmol of sodium fluorocitrate was injected into hindlimb (motor-sensory) cortex. Extra-dural EEG electrodes were implanted after which the anaesthesia was ceased. EEG was recorded at 1, 3, 5, 7, 24 and 48 hours. There was a broad-band reduction in frequencies in the EEG between 20 and 100 Hz commencing within 1 hour of injection and largely restricted to the side of injection and to frontal cortex, and maximal at 3 hours. Halothane had a suppressive effect on gamma power after citrate injection, but also prevented EEG suppression caused by fluorocitrate, consistent with the hypothesis that some of the action of fluorocitrate depended on gap-junctions. The findings are consistent with the hypothesis that primary astroglial dysfunction leads to reduced neuronal transmission and further supports gap-junctions as mediating fluorocitrate-induced astroglial effects.

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AnimalsAstrocytesCitratesElectroencephalographyGap JunctionsMaleMotor CortexRatsRats, WistarJournal ArticleResearch Support, Non-U.S. Gov't

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J O Willoughby, L Mackenzie, K J Pope, M Broberg, M Nilsson. 2004-09-10. Localised astroglial dysfunction disrupts high-frequency EEG rhythms.. https://doi.org/10.1007/s00702-004-0189-9

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