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PubMed · 15368969

[Atomic force microscopy: from cell imaging to molecular manipulation].

Pierre-Emmanuel Milhiet·Patrice Dosset·Marie-Cécile Giocondi·Christian Le Grimellec
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Abstract

The atomic force microscope (AFM) allows to explore the surface of biological samples bathed in physiological solutions, with vertical and horizontal resolutions ranging from nanometers to angströms. Complex biological structures as well as single molecules can be observed and recent examples of the possibilities offered by the AFM in the imaging of intact cells, isolated membranes, membrane model systems and single molecules are discussed in this review. Applications where the AFM tip is used as a nanotool to manipulate biomolecules and to determine intra and intermolecular forces from single molecules are also presented.

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AnimalsCell MembraneCholera ToxinHumansMicroscopy, Atomic ForceModels, MolecularRhodopseudomonasSensitivity and SpecificityEnglish AbstractJournal ArticleReview

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Pierre-Emmanuel Milhiet, Patrice Dosset, Marie-Cécile Giocondi, Christian Le Grimellec. 2004. [Atomic force microscopy: from cell imaging to molecular manipulation].. https://pubmed.ncbi.nlm.nih.gov/15368969/

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