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1,2-Ethanedithiol-induced erythema multiforme-like contact dermatitis.

Jeng-Wei Tjiu·Chia-Yu Chu·Chee-Ching Sun
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Abstract

Contact dermatitis simulating erythema multiforme can be caused by many allergens. The chemical agent 1,2-ethanedithiol, which serves as a protective group in chemical synthesis, has hitherto only been implicated as an irritant. We report on a 22-year-old female chemistry student who developed widespread erythema multiforme-like lesions after local contact with 1,2-ethanedithiol. Many target lesions were observed bilaterally on her hands, forearms, arms, and on her forehead. One such lesion was histologically compatible with erythema multiforme. The patient had a positive patch test to 1,2-ethanedithiol, whereas none of 30 healthy subjects showed a positive reaction. However, eight of the 30 controls (26.7%) developed irritant reactions to 1,2-ethanedithiol. Cautious handling of the compound is a prudent precaution.

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Adrenal Cortex HormonesAdultDermatitis, ContactDiagnosis, DifferentialErythema MultiformeEthylene GlycolFemaleHumansIrritantsMaleMethylprednisoloneMiddle AgedPatch TestsPrednisoloneCase ReportsJournal Article

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Jeng-Wei Tjiu, Chia-Yu Chu, Chee-Ching Sun. 2004. 1,2-Ethanedithiol-induced erythema multiforme-like contact dermatitis.. https://doi.org/10.1080/00015550410033571

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