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CO sniffing through heme-based sensor proteins.

Paolo Ascenzi·Alessio Bocedi·Livia Leoni·Paolo Visca·Elisabetta Zennaro·Mario Milani·Martino Bolognesi
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Abstract

O(2), NO, and CO are substrates, products, and/or modulators in many enzymatic reactions including O(2) respiration, denitrification, N(2) fixation, and methanogenesis. Over the last decade, O(2), NO, and CO have been reported to act as signaling molecules in the control of several distinct biological functions. Here, the heme-based mechanisms of CO sensing by the bacterial homodimeric CooA and the mammalian heterodimeric NPAS2-BMAL1 transcriptional factors are reviewed, and the signal transduction pathways are discussed.

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AnimalsBacterial ProteinsBase SequenceBrainCarbon MonoxideHemeHemeproteinsHumansModels, MolecularMolecular Sequence DataOxidation-ReductionSignal TransductionTranscription FactorsJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Paolo Ascenzi, Alessio Bocedi, Livia Leoni, Paolo Visca, Elisabetta Zennaro, Mario Milani, Martino Bolognesi. 2004. CO sniffing through heme-based sensor proteins.. https://doi.org/10.1080/10258140412331286937

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