Ca2+ regulation and gene expression in normal brain aging.

Emil C Toescu; Alexei Verkhratsky; Philip W Landfield

doi:10.1016/j.tins.2004.07.010

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Ca2+ regulation and gene expression in normal brain aging.

Emil C Toescu·Alexei Verkhratsky·Philip W Landfield

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Abstract

Understanding the cellular mechanisms that characterize the functional changes of the aged brain is an ongoing and formidable challenge for the neuroscience community. Evidence now links changes in Ca(2+) influx and homeostasis with perturbations induced by the aging process in the function of the main intracellular organelles involved in Ca(2+) regulation: the endoplasmic reticulum and mitochondria. New perspectives are also offered by recent gene microarray studies, illustrating the multifactorial nature of the aging process.

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Aging Animals Brain Calcium Calcium Signaling Endoplasmic Reticulum Gene Expression Regulation Homeostasis Humans Mitochondria Neurons Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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Emil C Toescu, Alexei Verkhratsky, Philip W Landfield. 2004. Ca2+ regulation and gene expression in normal brain aging.. https://doi.org/10.1016/j.tins.2004.07.010

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