Regulatory evolution across the protein interaction network.

Bernardo Lemos; Colin D Meiklejohn; Daniel L Hartl

doi:10.1038/ng1427

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PubMed · 15378060

Regulatory evolution across the protein interaction network.

Bernardo Lemos·Colin D Meiklejohn·Daniel L Hartl

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Abstract

Protein-protein interactions may impose constraints on both structural and regulatory evolution. Here we show that protein-protein interactions are negatively associated with evolutionary variation in gene expression. Moreover, interacting proteins have similar levels of variation in expression, and their expression levels are positively correlated across strains. Our results suggest that interacting proteins undergo similar evolutionary dynamics, and that their expression levels are evolutionarily coupled. These patterns hold for organisms as diverse as budding yeast and fruit flies.

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Animals Drosophila Proteins Drosophila melanogaster Evolution, Molecular Gene Expression Genes, Fungal Genes, Insect Genetic Variation Genetics, Population Male Polymorphism, Genetic Proteins Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Journal Article Research Support, U.S. Gov't, P.H.S.

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Bernardo Lemos, Colin D Meiklejohn, Daniel L Hartl. 2004-09-19. Regulatory evolution across the protein interaction network.. https://doi.org/10.1038/ng1427

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