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PubMed · 15380510

Nuclear factor-kappaB: the enemy within.

Bharat B Aggarwal
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Abstract

Numerous lines of investigation suggest that nuclear factor NF-kappaB, a proinflammatory transcription factor, could promote tumorigenesis. Various inflammatory agents, carcinogens, tumor promoters, and the tumor microenvironment activate NF-kappaB. NF-kappaB proteins themselves and proteins regulated by it have been linked to cellular transformation, proliferation, apoptosis suppression, invasion, angiogenesis, and metastasis. Constitutively activated NF-kappaB is common in wide variety of tumors. Furthermore, there exists genetic evidence that NF-kappaB mediates tumorigenesis. Thus, suppression of NF-kappaB activation should be effective in the prevention and treatment of cancer.

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ApoptosisCell DivisionCell Transformation, NeoplasticHumansInflammationNF-kappa BNeoplasm MetastasisNeovascularization, PathologicOncogenesJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Review

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BibTeXRIS

Bharat B Aggarwal. 2004. Nuclear factor-kappaB: the enemy within.. https://doi.org/10.1016/j.ccr.2004.09.003

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