Latent TGF-beta binding proteins.

V Todorovic; V Jurukovski; Y Chen; L Fontana; B Dabovic; D B Rifkin

doi:10.1016/j.biocel.2004.03.011

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Latent TGF-beta binding proteins.

V Todorovic·V Jurukovski·Y Chen·L Fontana·B Dabovic·D B Rifkin

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Abstract

Latent TGF-beta binding proteins are multidomain proteins with a common, highly repetitive structural organization and partially overlapping expression patterns. Latent TGF-beta binding protein-1, -3 and -4 bind latent TGF-beta. TGF-betas are normally secreted as latent complexes, consisting of the mature TGF-beta dimer non-covalently bound to its processed propeptide dimer plus a latent TGF-beta binding protein. The latent TGF-beta binding protein is covalently bound to the propeptide. These binding proteins may perform at least two functions: structural, as components of the matrix, and regulatory, as modulators of TGF-beta availability.

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Animals Extracellular Matrix Humans Intracellular Signaling Peptides and Proteins Latent TGF-beta Binding Proteins Protein Binding Protein Isoforms Protein Structure, Tertiary Signal Transduction Transforming Growth Factor beta Journal Article Research Support, U.S. Gov't, P.H.S.Review

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V Todorovic, V Jurukovski, Y Chen, L Fontana, B Dabovic, D B Rifkin. 2005. Latent TGF-beta binding proteins.. https://doi.org/10.1016/j.biocel.2004.03.011

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